Genomic characterisation of the severe acute respiratory syndrome coronavirus of Amoy Gardens outbreak in Hong Kong.
Identifieur interne : 005F90 ( Main/Exploration ); précédent : 005F89; suivant : 005F91Genomic characterisation of the severe acute respiratory syndrome coronavirus of Amoy Gardens outbreak in Hong Kong.
Auteurs : S S C. Chim [République populaire de Chine] ; S K W. Tsui ; K C A. Chan ; T C C. Au ; E C W. Hung ; Y K Tong ; R W K. Chiu ; E K O. Ng ; P K S. Chan ; C M Chu ; J J Y. Sung ; J S Tam ; K P Fung ; M M Y. Waye ; C Y Lee ; K Y Yuen ; Y M D. LoSource :
- Lancet (London, England) [ 1474-547X ] ; 2003.
Descripteurs français
- KwdFr :
- Flambées de maladies (), Génome viral, Hong Kong (épidémiologie), Humains, Infection croisée (virologie), Syndrome respiratoire aigu sévère (diagnostic), Syndrome respiratoire aigu sévère (virologie), Syndrome respiratoire aigu sévère (épidémiologie), Séquence nucléotidique (génétique), Virus du SRAS (génétique).
- MESH :
- diagnostic : Syndrome respiratoire aigu sévère.
- génétique : Séquence nucléotidique, Virus du SRAS.
- virologie : Infection croisée, Syndrome respiratoire aigu sévère.
- épidémiologie : Hong Kong, Syndrome respiratoire aigu sévère.
- Flambées de maladies, Génome viral, Humains.
- Wicri :
- geographic : Hong Kong.
English descriptors
- KwdEn :
- Base Sequence (genetics), Cross Infection (virology), Disease Outbreaks (statistics & numerical data), Genome, Viral, Hong Kong (epidemiology), Humans, SARS Virus (genetics), Severe Acute Respiratory Syndrome (diagnosis), Severe Acute Respiratory Syndrome (epidemiology), Severe Acute Respiratory Syndrome (virology).
- MESH :
- geographic , epidemiology : Hong Kong.
- diagnosis : Severe Acute Respiratory Syndrome.
- epidemiology : Severe Acute Respiratory Syndrome.
- genetics : Base Sequence, SARS Virus.
- statistics & numerical data : Disease Outbreaks.
- virology : Cross Infection, Severe Acute Respiratory Syndrome.
- Genome, Viral, Humans.
Abstract
Severe acute respiratory syndrome (SARS) is a global health concern. In Hong Kong, two major outbreaks, one hospital based and the other in the Amoy Gardens apartments, were identified. The frequency of diarrhoea, admission to intensive care, and mortality differed significantly between the two outbreaks. We did genomic sequencing for viral isolates from five Amoy Gardens patients. The virus sequence was identical in four of these five patients. The sequence data from one hospital case and the four identical community cases had only three nucleotide differences. Alterations in the SARS coronavirus genome are unlikely to have caused the distinctive clinical features of the Amoy Gardens patients, and these results highlight the importance of non-viral genomic factors in this outbreak.
DOI: 10.1016/s0140-6736(03)14901-x
PubMed: 14654320
Affiliations:
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Chim</name><affiliation wicri:level="4"><nlm:affiliation>Department of Chemical Pathology, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Chemical Pathology, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Tsui, S K W" sort="Tsui, S K W" uniqKey="Tsui S" first="S K W" last="Tsui">S K W. Tsui</name></author><author><name sortKey="Chan, K C A" sort="Chan, K C A" uniqKey="Chan K" first="K C A" last="Chan">K C A. Chan</name></author><author><name sortKey="Au, T C C" sort="Au, T C C" uniqKey="Au T" first="T C C" last="Au">T C C. 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Sung</name></author><author><name sortKey="Tam, J S" sort="Tam, J S" uniqKey="Tam J" first="J S" last="Tam">J S Tam</name></author><author><name sortKey="Fung, K P" sort="Fung, K P" uniqKey="Fung K" first="K P" last="Fung">K P Fung</name></author><author><name sortKey="Waye, M M Y" sort="Waye, M M Y" uniqKey="Waye M" first="M M Y" last="Waye">M M Y. Waye</name></author><author><name sortKey="Lee, C Y" sort="Lee, C Y" uniqKey="Lee C" first="C Y" last="Lee">C Y Lee</name></author><author><name sortKey="Yuen, K Y" sort="Yuen, K Y" uniqKey="Yuen K" first="K Y" last="Yuen">K Y Yuen</name></author><author><name sortKey="Lo, Y M D" sort="Lo, Y M D" uniqKey="Lo Y" first="Y M D" last="Lo">Y M D. Lo</name></author></analytic><series><title level="j">Lancet (London, England)</title><idno type="eISSN">1474-547X</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Base Sequence (genetics)</term><term>Cross Infection (virology)</term><term>Disease Outbreaks (statistics & numerical data)</term><term>Genome, Viral</term><term>Hong Kong (epidemiology)</term><term>Humans</term><term>SARS Virus (genetics)</term><term>Severe Acute Respiratory Syndrome (diagnosis)</term><term>Severe Acute Respiratory Syndrome (epidemiology)</term><term>Severe Acute Respiratory Syndrome (virology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Flambées de maladies ()</term><term>Génome viral</term><term>Hong Kong (épidémiologie)</term><term>Humains</term><term>Infection croisée (virologie)</term><term>Syndrome respiratoire aigu sévère (diagnostic)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Syndrome respiratoire aigu sévère (épidémiologie)</term><term>Séquence nucléotidique (génétique)</term><term>Virus du SRAS (génétique)</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Hong Kong</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Base Sequence</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Séquence nucléotidique</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Disease Outbreaks</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infection croisée</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Cross Infection</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Hong Kong</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Genome, Viral</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Flambées de maladies</term><term>Génome viral</term><term>Humains</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Hong Kong</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is a global health concern. In Hong Kong, two major outbreaks, one hospital based and the other in the Amoy Gardens apartments, were identified. The frequency of diarrhoea, admission to intensive care, and mortality differed significantly between the two outbreaks. We did genomic sequencing for viral isolates from five Amoy Gardens patients. The virus sequence was identical in four of these five patients. The sequence data from one hospital case and the four identical community cases had only three nucleotide differences. Alterations in the SARS coronavirus genome are unlikely to have caused the distinctive clinical features of the Amoy Gardens patients, and these results highlight the importance of non-viral genomic factors in this outbreak.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Sha Tin</li></settlement><orgName><li>Université chinoise de Hong Kong</li></orgName></list><tree><noCountry><name sortKey="Au, T C C" sort="Au, T C C" uniqKey="Au T" first="T C C" last="Au">T C C. Au</name><name sortKey="Chan, K C A" sort="Chan, K C A" uniqKey="Chan K" first="K C A" last="Chan">K C A. Chan</name><name sortKey="Chan, P K S" sort="Chan, P K S" uniqKey="Chan P" first="P K S" last="Chan">P K S. Chan</name><name sortKey="Chiu, R W K" sort="Chiu, R W K" uniqKey="Chiu R" first="R W K" last="Chiu">R W K. Chiu</name><name sortKey="Chu, C M" sort="Chu, C M" uniqKey="Chu C" first="C M" last="Chu">C M Chu</name><name sortKey="Fung, K P" sort="Fung, K P" uniqKey="Fung K" first="K P" last="Fung">K P Fung</name><name sortKey="Hung, E C W" sort="Hung, E C W" uniqKey="Hung E" first="E C W" last="Hung">E C W. Hung</name><name sortKey="Lee, C Y" sort="Lee, C Y" uniqKey="Lee C" first="C Y" last="Lee">C Y Lee</name><name sortKey="Lo, Y M D" sort="Lo, Y M D" uniqKey="Lo Y" first="Y M D" last="Lo">Y M D. Lo</name><name sortKey="Ng, E K O" sort="Ng, E K O" uniqKey="Ng E" first="E K O" last="Ng">E K O. Ng</name><name sortKey="Sung, J J Y" sort="Sung, J J Y" uniqKey="Sung J" first="J J Y" last="Sung">J J Y. Sung</name><name sortKey="Tam, J S" sort="Tam, J S" uniqKey="Tam J" first="J S" last="Tam">J S Tam</name><name sortKey="Tong, Y K" sort="Tong, Y K" uniqKey="Tong Y" first="Y K" last="Tong">Y K Tong</name><name sortKey="Tsui, S K W" sort="Tsui, S K W" uniqKey="Tsui S" first="S K W" last="Tsui">S K W. Tsui</name><name sortKey="Waye, M M Y" sort="Waye, M M Y" uniqKey="Waye M" first="M M Y" last="Waye">M M Y. Waye</name><name sortKey="Yuen, K Y" sort="Yuen, K Y" uniqKey="Yuen K" first="K Y" last="Yuen">K Y Yuen</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Chim, S S C" sort="Chim, S S C" uniqKey="Chim S" first="S S C" last="Chim">S S C. Chim</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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